Organocatalytic Mitsunobu Reactions
Автор: The Cyclo Edition
Загружено: 2019-09-09
Просмотров: 1414
In this episode we analyze a new paper from the Denton lab where they report a redox-neutral organocatalytic Mitsunobu reaction eliminating the need for stoichiometric, hazardous reagents.
DOI: 10.1126/science.aax3353
References:
Beddoe, R. H.; Andrews, K. G.; Magné, V.; Cuthbertson, J. D.; Saska, J.; Shannon-Little, A. L.; Shanahan, S. E.; Sneddon, H. F.; Denton, R. M. Redox-Neutral Organocatalytic Mitsunobu Reactions. Science 2019, 365, 910–914.
An, J.; Denton, R. M.; Lambert, T. H.; Nacsa, E. D. The Development of Catalytic Nucleophilic Substitution Reactions: Challenges, Progress and Future Directions. Org. Biomol. Chem. 2014, 12, 2993-3003.
Mitsunobu, O.; Yamada, M. Preparation of Esters of Carboxylic and Phosphoric Acid via Quaternary Phosphonium Salts . Bull. Chem. Soc. Jpn. 1967, 40, 2380–2382.
Mitsunobu, O. The Use of Diethyl Azodicarboxylate and Triphenylphosphine in Synthesis and Transformation of Natural Products. Synthesis 1981, 1981, 1–28.
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Tang, X.; Chapman, C.; Whiting, M.; Denton, R. Development of a Redox-Free Mitsunobu Reaction Exploiting Phosphine Oxides as Precursors to Dioxyphosphoranes. Chem. Commun. 2014, 50, 7340–7343.
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Kurti, L.; Czako, B. Strategic Applications of Named Reactions in Organic Synthesis; Elsevier: Burlington, 2005.
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