Particle Micronization: A Tool for Enabled Pharmaceutical Formulations
Автор: Capsugel
Загружено: 2016-04-01
Просмотров: 4256
Micronization is an enabling technology providing effective particle engineering for a range of pharmaceutical formulations applications. Micronization of crystalline API is a well-established approach for increasing the surface area, thereby improving the oral bioavailability of drugs whose absorption is dissolution-rate limited, i.e. developability classification system (DCS) IIa drugs. The technology is complementary to other delivery technologies for bioavailability enhancement, such as solid amorphous dispersions, that are applicable to drugs whose absorption is solubility-limited. Other micronization applications for oral delivery include jet milling of API or excipients for microparticle coating applications where particle size distribution is critical. Micronization can be tailored to the optimum particle size, distribution and fine particle fraction required for specific applications and target product profile desired.
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