Improving the Synthesis and Stability of Psilocin Derivatives
Автор: Simplifying Synthesis
Загружено: 2025-05-31
Просмотров: 1190
A medicinal chemistry minilecture on the 'Synthesis and In Vitro Profiling of Psilocin Derivatives: Improved Stability and Synthetic Properties' by Julia Eklund, Ulf Bremberg,* Jessica Larsson, Edvard Torkelsson, Johan Wennerberg,* Symantha Zandelin, and Luke R. Odell*. It explains the metabolism of psilocybin and how this can be modified to produce more active psilocin analogues. An improved chemical synthesis of psilocin esters is explained along with strategies to improve the stability and manufacture of psilocin salts.
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References:
J. Med. Chem. 2025, 68, 7, 7153–7165 (This work)
Clin. Pharmacokinet. 2017, 56,1543−1554 (Psilocybin Metabolism)
Pharm. Acta Helv. 1997, 72, 175−184 (Psilocybin Metabolism)
ACS Omega 2020, 5, 16959−16966 (Previous Synthesis of Psilocybin)
US11680043B2, June 20 2023 (Patent on Psilocin Salts)
ADME Encyclopedia 2022, 379−387. (Challenges of using micosomal assays with esterase labile compounds)
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