The Future of Aging with Dr Aubrey de Grey

Google's Calico has struggled despite substantial resources.

Regulatory innovation emerges as a crucial accelerator for progress. Montana's groundbreaking expansion of Right to Try legislation now allows anyone to access treatments that have passed FDA safety trials, while special economic zones like Prospera in Honduras are creating regulatory environments specifically designed for biomedical innovation. These developments could create the competitive pressure needed to modernize traditional regulatory structures worldwide.

At the LEV Foundation, Dr. de Grey is conducting a thousand-mouse study combining four different damage repair interventions in middle-aged mice, aiming for a full year of life extension—far beyond the four months typically achieved. Unlike conventional approaches that rely on dietary modifications, this ambitious project incorporates advanced cell and gene therapies that target multiple forms of age-related damage simultaneously.

Looking forward, Dr. de Grey offers his characteristic probabilistic prediction: a 50-50 chance of reaching "longevity escape velocity" within 12-15 years. This would enable taking 60-year-olds and rejuvenating them enough that they wouldn't be biologically 60 again for another 20 years, during which time further advances would enable additional rejuvenation cycles—potentially creating open-ended healthy lifespans for many alive today.