Cocaine: Use, Abuse, Overdose, Toxicology.

Cocaine is one of the most dangerous drugs of abuse, but also the most common. Its history dates back thousands of years to the ancient people of South America.

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Please note, this video is not medical advice

The main effects of cocaine are:
Autonomic
Central Nervous System
Cardiovascular

Treatment of cocaine toxicity involves:
Aggressive management of agitation and hyperthermia
Management of cardiovascular complications
Management of seizures or other neurological complications

References:
Goldstein RA, DesLauriers C, Burda A, Johnson-Arbor K. Cocaine: history, social implications, and toxicity: a review. Semin Diagn Pathol. 2009 Feb;26(1):10-7. doi: 10.1053/j.semdp.2008.12.001. PMID: 19292024.

 Brody SL, Slovis CM, Wrenn KD. Cocaine-related medical problems: consecutive series of 233 patients. Am J Med 1990;88(4):325–31. 
 Ferreira S, Crumb WJ, Jr., Carlton CG, Clarkson CW. Effects of cocaine and its major metabolites on the HERG-encoded potassium channel. J Pharmacol Exp Ther 2001;299(1):220–6

Richards JR, Garber D, Laurin EG, Albertson TE, Derlet RW, Amsterdam EA, et al. Treatment of cocaine cardiovascular toxicity: a systematic review. Clin Toxicol (Phila) 2016;54(5):345–64.

Wood DM, Dargan PI, Hoffman RS. Management of cocaine-induced cardiac arrhythmias due to cardiac ion channel dysfunction. Clin Toxicol (Phila) 2009;47(1):14–23