Biomedical tools for environmental needs; Stem cell therapy for corals - Benyamin Rosental
Автор: Foo Camp
Загружено: 2024-08-20
Просмотров: 34
Reef corals are the foundation of ecosystems that host much of the ocean’s biodiversity. They are under severe threat from anthropogenic stressors, particularly global warming. Efforts to mitigate the damage are informed by research on understanding and transferring naturally-occurring resilient genotypes. This has a direct parallel in medicine; cell- or gene-therapy, which is founded on an ability to isolate and then transplant stem cells. This ability/technology does not exist for any Hexacorallian species. We are developing robust tools for the isolation, characterization, and transplantation of Hexacorallian stem cells.
#BenyaminRosental #scifoo #coral #coral #ecosystem
Our aim is to develop the transformation of resilience through stem cell therapy, using stem cell transplantation. We currently succeed in Nematostella vectensis as a model. We showed the integration and proliferation of the transplanted cells into the tissue. Additionally, we showed cell integration and transfer of phenotypes, showing the potential of cell therapy in Hexacorallians. We showed the longevity and wound healing of our candidate stem cells. Finally, we showed that the candidate stem cell transplantation can rescue animals from a lethal chemotherapy treatment.
Moreover, since we are using species-non-specific methods, we show our capability of isolating candidate stem cells from other Hexacorallian species, including stony corals. We have succeeded in transplanting two species of stony corals. In this work, we utilize medical approaches toward ecological problems, opening new frontiers for stem cell-based therapy.
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