Why Your Glucose Spikes When You Exercise? | Dr. Robert Lustig Ultimate Guide

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Levels Advisor Robert Lustig, MD, explains what happens with your glucose levels when you exercise—and when you stop.

When you exercise, you may see a glucose spike on your CGM. That’s expected and nothing to worry about.

Exercise activates your sympathetic nervous system, aka your fight-or-flight response. This signals your liver to release glycogen (stored glucose) into your bloodstream, raising your glucose level. The glucose powers your muscles, brain, and other organs. When you stop exercising, you’ll clear that spike rapidly. This type of spike is not harmful.

If you exercise for a long duration (about three hours), you’ll use up all your glycogen. In marathon running, this moment is called “hitting the wall.” As your body switches over to mainly using fat for fuel, you may feel fatigued and as if you can’t keep going.

The sport drink industry puts fructose in its products for this reason. That fructose will get converted to glucose to keep powering your exercise efforts. However, most people don’t need glucose unless they are exercising for long durations.

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