ESC HF 25: PRAISE-HFrEF: Glucagon-Like Peptide-1 Receptor Agonism in HFrEF and Obesity
Автор: Radcliffe Cardiology
Загружено: 2025-05-17
Просмотров: 206
ESC HF 25 - Safety outcomes from PRAISE-HFrEF show that glucagon-like peptide-1 receptor agonism (GLP-1 RA) treatment for heart failure with reduced ejection fraction (HFrEF) and obesity was not associated with increased risk of heart failure hospitalisation or mortality compared to placebo, with greater benefits observed in patients with higher BMI.
Dr Varun Sundaram (Case Western Reserve University, Cleveland, US) discusses the findings from PRAISE-HFrEF, a pharmacoepidemiologic study investigating the safety of a GLP-1 RA in patients with HFrEF and obesity across 170 hospitals within the US. The primary outcome measure as time to first hospitalization for heart failure or all-cause mortality.
Findings showed that during a median follow-up period of 3.3 years, there was no increased risk for the composite of heart failure hospitalisation or mortality in the GLP-1 RA group as compared to placebo. A subgroup analysis found that patients with increased BMI experienced a greater effect of GLP-1 treatment in terms of the primary outcome.
Interview Questions:
1. How does the pathophysiology of HFrEF with concurrent obesity potentially create a therapeutic opportunity for GLP-1RAs?
2. What was the study design and patient population?
3. What were the key findings?
4. How do the findings from PRAISE-HFrEF complement what we're learning about GLP-1RAs from other cardiovascular outcome trials like SURMOUNT-CV or FLOW?
5. What are the next steps?
Recorded on-site at ESC HF in Belgrade, 2025.
Editors: Jordan Rance, Yazmin Sadik
Videographers: Tom Green, Mike Knight
Support: This is an independent interview produced by Radcliffe CVRM.
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