What You Need to Know About Packing Resins at Process Scale

Learn best practices and guidelines for successfully packing different types of chromatography resins. This includes incompressible resins like CHT Ceramic Hydroxyapatite Media as well as traditional compressible resins. CHT is an easy-to-use mixed-mode media and has high specific gravity, a rapid settling rate, and sensitivity to mechanical shear. These variations from traditional compressible resins must be considered when designing CHT column-packing protocols. In general, parameters such as compression factor, settling rate, and attributes of the base matrix need to be considered when packing resins at process scale. Packing methods can be adapted to obtain simple and the most reproducible packing.


Overview

- Differences between compressible and incompressible resins
- Slurry preparation techniques
Slurry transfer methodologies
Column packing guidelines
Packed column evaluation and qualification testing
- A word about height equivalent to a theoretical plate (HETP)

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