Session 3: Clinical Case Presentations with Panel

Description:

Presenters:
Sibongiseni Sanele Malinga, MBChB, Dip HIV Man (SA) - King Edward VII Hospital
Michael Hawkes, BEng, MD, PhD, DTM&H, FRCPC - University of Alberta
Lecture: Clinical Case Presentations with Panel
Presented in Session 3: Comorbidities/Co-Infections

International Workshop on HIV & Pediatrics 2022
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Meeting Description
The 14th International Workshop on HIV & Pediatrics took place as a hybrid meeting from 27-28 July 2022 in Montreal, Canada.

Although we have witnessed a dramatic global scale-up of antiretroviral treatment (ART) as well as efforts to prevent vertical HIV transmission in the last decade, there were 160,000 new pediatric infections in 2018 and an estimated 1.7 million children under 15 years of age living with HIV. Children are substantially less likely than adults to be diagnosed, initiate treatment, and achieve durable viral suppression. Currently, only 54% are receiving ART, and treatment of pediatric HIV infection, particularly in infants and young children, remains complex and problematic, with continued use of suboptimal ART formulations and regimens.

Furthermore, adolescents are one of the most rapidly growing populations with HIV; in 2018, there were an estimated 510,000 new HIV infections among young people aged 15- 24 years, accounting for 30% of all new HIV infections globally. HIV infections among adolescent girls and young women are 60% higher than among adolescent boys and young men of the same age, with 6,000 new infections occurring in young women weekly. HIV remains one of the leading causes of death among adolescents living in Africa and among the top 10 causes of death in adolescents globally. The uptake of HIV testing among adolescents has remained low. Programs continue to struggle to reach and retain adolescents in care, and adherence to treatment has special challenges, particularly among those with perinatal infection aging up into adolescence and young adulthood.

As research to improve pediatric HIV diagnosis and care is ongoing, new scientific questions of critical importance have also emerged. In settings with mature ART programs, an increasing proportion of new pediatric infections is attributed to women acquiring HIV infection during pregnancy and breastfeeding, periods of markedly increased risk of HIV acquisition for the mother. With the scale-up of ART for PMTCT, the prevalence of pre-treatment antiretroviral (ARV) drug resistance, particularly to non-nucleoside reverse transcriptase inhibitor drugs, has escalated among newly diagnosed infants, jeopardizing ART effectiveness. Additionally, with more than 1.3 million pregnant women globally receiving ART, there are increasing concerns about the long-term impact of in utero and postnatal exposures to medications for those children who escape HIV.

Currently, the global population of HIV-exposed uninfected children and adolescents is estimated at 14.8 million, including over 8 million with in utero ARV exposure. Recent findings of an association with periconception dolutegravir exposure and increased risk of neural tube defects have underscored the need for ongoing attention to the safety of ARVs in pregnancy. Innovation in early infant diagnosis such as point of- care tests has facilitated earlier identification of HIV infection during infancy, providing exciting new opportunities to study acute infection and very early treatment in neonates and promising remission strategies. However, despite the critical importance of these topics, research in pediatric, adolescent, and maternal HIV infection is often neglected at major scientific HIV conferences.

Therefore, in collaboration with leading experts in the field, we have established a highly focused international workshop on the prevention and treatment of pediatric HIV infection. The overall objective of the International Workshop on HIV Pediatrics is to stimulate research that will advance prevention and treatment strategies for infants, children, and adolescents.