Treatment of Prostate Cancer: Androgen Deprivation Therapy (ADT) and Radiation with Dr. Mira Keyes
Автор: Grand Rounds in Urology
Загружено: 2025-09-17
Просмотров: 796
Mira Keyes, MD, FRCPC, FABS, British Columbia Cancer Agency, Vancouver, British Columbia, Canada, discusses the role of androgen deprivation therapy (ADT) combined with radiation for prostate cancer treatment. In this 13-minute presentation, Dr. Keyes offers valuable insights into balancing ADT benefits with potential harms to improve outcomes in prostate cancer management.
Dr. Keyes highlights data from randomized controlled trials, emphasizing that adding ADT to radiation significantly improves overall survival, particularly in high-risk patients. While longer ADT durations yield better outcomes, she warns of substantial side effects such as cognitive dysfunction, osteoporosis, and cardiovascular risks. She also explores the potential advantage of using ADT antagonists over agonists. The discussion underscores the importance of individualized treatment, advising careful consideration of patient age, comorbidities, and cardiac history.
Dr. Keyes highlights strategies to minimize ADT use. Emphasizing the need for multidisciplinary care, she recommends referring patients with cardiovascular risks to cardiologists for optimal management. Her presentation offers valuable insights into balancing ADT benefits with potential harms to improve outcomes in prostate cancer management.
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