Pituitary Tumor & CSF Leak: 4 Dangerous Mechanisms Explained Dr. Raghvendra Ramdasi

Many people are surprised to learn that a pituitary tumor can sometimes cause clear fluid to leak from the nose. This condition is called CSF Rhinorrhea, and it can be dangerous if ignored.

In this video, the doctor explains the exact mechanisms by which brain fluid (CSF) reaches the nose in patients with pituitary tumors.
1️⃣ Large, invasive pituitary tumors
Slow-growing pituitary tumors can erode the thin bone (sella turcica) and brain coverings, creating a direct pathway between the brain and the nasal sinuses—allowing CSF to leak from the nose.

2️⃣ Medical treatment of Prolactinoma
When pituitary tumors shrink after medications like Cabergoline or Bromocriptine, a previously blocked hole may get exposed—leading to sudden CSF leakage.

3️⃣ Pituitary apoplexy (bleeding inside the tumor)
Sudden bleeding increases pressure inside the brain, causing rupture of thin bone and membranes, resulting in CSF rhinorrhea.

4️⃣ Post-operative CSF leak
If skull base reconstruction after pituitary surgery is not completely sealed, CSF can leak as a post-surgical complication.

⚠️ Clear, watery discharge from the nose should never be ignored, especially if it increases on bending forward. Early diagnosis and proper treatment can prevent serious infections like meningitis.

👉 Watch till the end to understand why CSF rhinorrhea happens and when it becomes an emergency.
👉 Understanding pituitary anatomy helps patients better understand pituitary tumors, CSF leaks, and modern endoscopic skull-base surgeries.
📍 Doctor: Dr. Raghvendra Ramdasi
🧠 Specialty: Neurosurgeon
🏥 Location: Mumbai
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