Reactions of Epoxides | Organic Chemistry Lessons

In this video, we look at epoxides (oxacyclopropanes) and why their properties makes them especially sensitive to ring-opening reactions. Ring strain and polarity allow epoxides to open under acidic and basic conditions, giving a wide variety of nucleophilic additions. Reducing agents like lithium aluminum hydride (LAH), as well as Grignard and alkyllithium reagents, can also open epoxides. We also study the regioselectivity and stereoselectivity of these reactions with both acids and bases, helping us expand our toolbox of synthetic methods in organic chemistry.

SN2 Review:    • SN2 Reaction and Mechanism | Organic Chemi...  
Ring Strain Review:    • Cycloalkanes and Ring Strain | Organic Che...  
Hydride Reductions Lesson:    • Hydride Reductions of Carbonyls | Organic ...  
Grignard Reagents Lesson:    • Grignard & Alkyllithium Reagents | Organic...  
SN1 Review:    • SN1 Reaction and Mechanism | Organic Chemi...  

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