🩺 HIV in Adults (Members Edition: Slides via QR) | ARV Mechanisms, First-Line ART, Vaccines & more 💊

🎁 Plus & Pro Members Perk: Scan the QR code shown in this video to download the full slide deck (PDF) for personal study and rotation prep. Not a member yet? Join Plus/Pro to unlock slides for this and future masterclasses.

🚀 Welcome to the members-only HIV masterclass! Built for NAPLEX, CPJE, and USMLE prep and clinic, this all-in-one session turns guidelines into clear, defensible bedside decisions—from how ARVs block the HIV life-cycle to first-line regimens, vaccines, monitoring, and counseling.

Here’s what you’ll master:

1️⃣ HIV life-cycle + how ARVs stop it 🧬✂️
Map attachment → fusion → reverse transcription → integration → transcription/translation → assembly → budding/maturation, then see where entry/fusion/CCR5 antagonists, NRTIs/NNRTIs, INSTIs, and PIs block replication and maturation.
Learning Objective 1: Describe the HIV life-cycle and the mechanism of action of antiretroviral agents.

2️⃣ First-line ART, fast & DHHS-aligned 🎯💊
Build a quick selection pathway for treatment-naïve HIV-1 using patient factors (HBV coinfection, renal/bone health, pregnancy potential, CV risk, HLA-B*57:01, DDIs). Expect INSTI-based regimens such as bictegravir/TAF/FTC or dolutegravir + TAF/FTC (or TDF/FTC) with scenario-based tweaks.
Learning Objective 2: Given a treatment-naïve HIV-1 patient, recommend DHHS guideline-concordant antiretroviral therapy.

3️⃣ Vaccines that protect people with HIV 💉🛡️
Plan for influenza (annual), pneumococcal strategy, Td/Tdap, HepA/HepB, HPV, MenACWY, COVID-19; know when live vaccines are inappropriate by CD4/clinical status.
Learning Objective 3: When indicated, recommend immunization to patients living with HIV.

4️⃣ Monitoring to “undetectable” 📋📈
Design a lean plan: baseline (HIV RNA, CD4, genotype, HLA-B*57:01 if abacavir, renal/hepatic panel, lipids/glucose, HBV/HCV serologies, pregnancy test when relevant), follow-up HIV RNA at 2–8 weeks until undetectable, periodic CD4, safety labs & DDI checks, ongoing adherence/access support.
Learning Objective 4: Given a patient with HIV, design an individualized monitoring plan.

5️⃣ Counseling: side effects & administration 🗣️💬
Set expectations for common AEs (GI upset, headache, sleep changes), rare but serious warnings, administration tips (e.g., INSTIs + polyvalent cations ⛔️🪨), missed-dose plans, high-risk DDIs (acid suppressants, anticonvulsants, rifamycins, herbal products), pregnancy planning, and adherence strategies.
Learning Objective 5: Given a prescription for antiretroviral agents, provide patient counseling for adverse effects and proper administration.

✨ Members get slides via QR + the full lecture to build a repeatable, exam-ready HIV toolkit—mechanisms → regimen picks → vaccines → monitoring → counseling.

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