Three Molecular Subtypes of ALS:

In this episode of the EverythingALS Expert Talk Series, Dr. Molly Gale Hammell, Associate Professor at the Institute for Systems Genetics, NYU Langone Medical Center, explores the three molecular subtypes of ALS — stress, inflammation, and TDP-43 pathology. She shares insights into how these distinct pathways contribute to ALS progression and potential avenues for targeted treatments.

⏱ Timestamps:
00:00 - Introduction
02:15 - Understanding ALS at a molecular level
05:40 - The role of cellular stress in ALS
12:20 - Inflammation and its impact on disease progression
18:45 - TDP-43 pathology: Key mechanisms and implications
25:10 - Potential therapeutic strategies
30:00 - Q&A and audience discussion

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