Identification of unprecedented binding sites by electrophilic MiniFrags
Автор: Enamine Ltd
Загружено: 2024-10-25
Просмотров: 117
Watch our webinar with Dr. György Miklós Keserű “Identification of unprecedented binding sites by electrophilic MiniFrags” to learn how we developed the covalent alternatives of Astex's MiniFrags that allow mapping potential binding sites for covalent inhibitors.
Covalent MiniFrags are 5- and 6-membered electrophilic heterocycles that covalently bond at their binding site. Screening hits can be identified by simple biochemical assay, and the binding site can be located by mass spectrometry. The utility of this methodology was demonstrated by discovering novel covalent 3CLPro inhibitors and the first leadlike covalent inhibitor of HDAC8.
About Organizer:
Enamine is the leading producer and supplier of building blocks and compounds libraries for drug discovery, serving the industry since 1991. The company is a developer of cutting-edge technology for generating ultra-large chemical spaces for hit discovery, with molecules accessible with 80%+ rate, within 3-4 weeks. The technology is based on the world's largest stock of building blocks and proprietary framework for compound library synthesis.
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