Oral Relief, Biomarkers and Prevention: OrthoNu with Dr. Sima Yakoby Epstein

What happens when an orthodontist who lived through years of dental trauma as a teen decides patients deserve better between visits? In this episode of Patient Win Insider, host Nick Moen talks with Dr. Sima Yakoby Epstein, founder and CEO of OrthoNu, an oral–systemic wellness company building tools for emergencies, diagnostics and wound healing that actually follow patients home.

Dr. Yakoby Epstein shares how a childhood car accident, a decade in clinical practice and the chaos of COVID all pushed her to close the gap between chairside care and real life. She walks through OrthoNu’s three pillars: the Oral Relief collection (Tweakz, Mouth Aid, Comfort Tape, Chillin Strips and OrthoChoose) for orthodontic and post-procedure emergencies, new chairside SMART diagnostics for oral–systemic biomarkers, and regenerative strips that support post-op wound healing in the first critical 72 hours.

Along the way, she talks about oral microbiome science, salivary pH, prevention over crisis management and why she chose a B2B-to-consumer model that starts with trust at the dental office instead of the drugstore shelf.

In this episode, you will learn:
How a teen car accident and years as “the patient” shaped Dr. Yakoby Epstein’s obsession with comfort, empathy and self-care tools
Why OrthoNu’s Oral Relief collection was built to replace toenail clippers, makeshift pliers and wax that falls off in 30 seconds
How dissolvable, adhesive strips create new categories in both oral comfort and chronic wound care
Why salivary pH, the oral microbiome and simple at-home protocols can change risk for cavities, gingivitis and sensitivity
How chairside lateral-flow biomarker tests and future oral diagnostics could make dentists true “oral physicians” who help catch systemic issues earlier
What she looks for when building a team around her blind spots in business, operations and finance
Why she started B2B with dentists and orthodontists first, and how practices are bundling OrthoNu kits into their standard of care

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