Post-Prednisone Side Effects: What Happens After Stopping Prednisone?

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DATA:
1. https://pubmed.ncbi.nlm.nih.gov/25272...
2. https://pubmed.ncbi.nlm.nih.gov/23656...

This video explores the side effects that can emerge after stopping prednisone, a synthetic corticosteroid. It explains how long-term use suppresses natural cortisol production and why sudden discontinuation can lead to adrenal insufficiency or even adrenal crisis. The discussion covers physical symptoms like low blood pressure and blood sugar, as well as psychological effects such as mood swings and depression. Viewers will learn why tapering off prednisone gradually is essential, what symptoms to watch for, and how lifestyle changes can help ease the transition off the medication.

Key Takeaways:
1. Gradual Tapering is Essential: Stopping prednisone suddenly can trigger serious complications, including adrenal crisis. Tapering allows the adrenal glands to gradually resume natural cortisol production.
2. Increased Risk of Health Conditions: After stopping prednisone, people often experience the opposite of its active effects—issues like low blood pressure, low blood sugar, electrolyte disturbances, and digestive problems.
3. Psychological and Cognitive Effects: Withdrawal can bring emotional and mental challenges, such as depression, mood swings, irritability, and cognitive fog. These symptoms are more common in those who’ve been on prednisone long-term.
4. Factors Influencing Side Effects: The risk of withdrawal symptoms increases with longer treatment duration, higher cumulative doses, older age, and combining prednisone with medications like antibiotics.
5. Lifestyle and Management Strategies: Staying hydrated, eating a balanced diet, and avoiding physical stress can support recovery. Medical supervision and a slow tapering schedule are key to minimizing withdrawal effects.

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Dr. Megan is the Prednisone Pharmacist who experienced side effects from a prescription drug called prednisone. Here she teaches tips to deal with side effects naturally. Every week Dr. Megan posts a new video with an answer to your burning prednisone questions.

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