New drug can potentially regenerate hearing & treat hearing loss - Dr. Zheng-Yi Chen

In our latest podcast, we speak with Dr. Zheng-Yi Chen, Associate Professor at Harvard Medical School. Dr. Chen is leading the world in the field of hearing and treatments. Currently, there are no drug treatments for hearing loss. Dr. Chen and his team have now developed a potential treatment for treating hearing loss and to regenerate hearing. This can revolutionize the future of how we treat hearing loss.

Link to research: https://www.pnas.org/doi/10.1073/pnas...

0:00 - Introduction
1:34 - Causes of hearing loss
3:59- the impact of genes & environmental factors on hearing loss
5:56- the pathways that cause hearing loss
8:06- the impact of hair cells on hearing loss
10:55- Scope of hair cells and regeneration
15:25- steps of the study for regeneration of hair cells
17:27- compounds used for hair cell regeneration
18:21- which of these compounds are FDA approved
19:29- how the animal model was able to regenerate new hair cells using the treatment
22:06- how long did it take to see results for the animal model
23:23- link of hair cells and hearing
24:42- how to deliver the gene therapy into the ear
25:17- what was the ultimate goal of the study, and what is the next goal of the study
26:07- duration of the next phase of the study
28:25- delivery of previous gene therapies into the ear, and how it can influence the way this therapy will be delivered
29:27- how will success be measured and how can it be used in a clinical scenario
33:50- what needs to be seen in the next phase of the study to be successful
35:40- how soon can this potential treatment be available
37:30- will this therapy be a one time treatment or multiple time treatment
39:05- important findings; how hearing loss can be linked to other diseases like dementia
41:41- how are other gene therapies for hearing being administered
42:52- timeline of clinical trials for genetic hearing loss
45:27- Conclusion

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