Li Hai SEMPRE Usati ma NON LO SAPEVI

Scopri le fantastiche magliette di Pampling! Usa il codice "SUPPOSTE" e ottieni un omaggio! https://www.pampling.com/

Vuoi sostenere il canale e avere un accesso più diretto a Supposte Mentali? Abbonati ora e unisciti al nostro canale Telegram!
   / @suppostementali  

Hai mai preso un farmaco che in realtà non è ancora… un farmaco? Probabilmente sì, e non lo sapevi!
In questo video esploriamo il mondo dei profarmaci, molecole "dormienti" che si attivano solo dopo essere entrate nel nostro corpo.

Vedremo:
• Come funzionano davvero i profarmaci
• Perché vengono progettati così
• Esempi famosi: dall’aspirina alla codeina, dal testosterone undecanoato all’isavuconazolo
• I vantaggi nella cura del cancro e nella medicina personalizzata
• E le sfide ancora aperte in questo campo affascinante

Se ti incuriosiscono i meccanismi dietro i farmaci, la biochimica e le strategie di drug design dell’industria farmaceutica, questo video fa per te.

👉 Se il video ti è piaciuto lascia un like, condividilo e iscriviti al canale!

💬 Fammi sapere nei commenti se conoscevi già queste fantastiche molecole!

#Profarmaci #Farmaci #Farmacologia #Scienza #SupposteMentali #Medicina #CuriositàScientifiche #Biochimica #Testosterone #Chemioterapia #Aspirina #Codeina #MedicinaPersonalizzata

Fonti
Huttunen, K. M., Raunio, H., & Rautio, J. (2011). Prodrugs--from serendipity to rational design. Pharmacological reviews, 63(3), 750–771. https://doi.org/10.1124/pr.110.003459

Srinivas N. R. (2011). The rationality for using prodrug approach in drug discovery programs for new xenobiotics: opportunities and challenges. European journal of drug metabolism and pharmacokinetics, 36(2), 49–59. https://doi.org/10.1007/s13318-011-00...

Markovic, M., Ben-Shabat, S., & Dahan, A. (2020). Prodrugs for Improved Drug Delivery: Lessons Learned from Recently Developed and Marketed Products. Pharmaceutics, 12(11), 1031. https://doi.org/10.3390/pharmaceutics...

Lambert D. M. (2000). Rationale and applications of lipids as prodrug carriers. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 11 Suppl 2, S15–S27. https://doi.org/10.1016/s0928-0987(00...

Jana, S., Mandlekar, S., & Marathe, P. (2010). Prodrug design to improve pharmacokinetic and drug delivery properties: challenges to the discovery scientists. Current medicinal chemistry, 17(32), 3874–3908. https://doi.org/10.2174/0929867107932...

Dhaneshwar, S. S., & Vadnerkar, G. (2011). Rational design and development of colon-specific prodrugs. Current topics in medicinal chemistry, 11(18), 2318–2345. https://doi.org/10.2174/1568026117971...

Hurwitz, S. J., & Schinazi, R. F. (2013). Prodrug strategies for improved efficacy of nucleoside antiviral inhibitors. Current opinion in HIV and AIDS, 8(6), 556–564. https://doi.org/10.1097/COH.000000000...

Damião, M. C., Pasqualoto, K. F., Polli, M. C., & Parise Filho, R. (2014). To be drug or prodrug: structure-property exploratory approach regarding oral bioavailability. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 17(4), 532–540. https://doi.org/10.18433/j3bs4h

Jornada, D. H., dos Santos Fernandes, G. F., Chiba, D. E., de Melo, T. R., dos Santos, J. L., & Chung, M. C. (2015). The Prodrug Approach: A Successful Tool for Improving Drug Solubility. Molecules (Basel, Switzerland), 21(1), 42. https://doi.org/10.3390/molecules2101...

Dahan, A., Zimmermann, E. M., & Ben-Shabat, S. (2014). Modern prodrug design for targeted oral drug delivery. Molecules (Basel, Switzerland), 19(10), 16489–16505. https://doi.org/10.3390/molecules1910...

Hunter, F., Wouters, B. & Wilson, W. Hypoxia-activated prodrugs: paths forward in the era of personalised medicine. Br J Cancer 114, 1071–1077 (2016). https://doi.org/10.1038/bjc.2016.79

Sheikh, S., Ernst, D., & Keating, A. (2021). Prodrugs and prodrug-activated systems in gene therapy. Molecular therapy : the journal of the American Society of Gene Therapy, 29(5), 1716–1728. https://doi.org/10.1016/j.ymthe.2021....

Prodrugs and their activation mechanisms for brain drug delivery. RSC medicinal chemistry, 10.1039/d4md00788c. Advance online publication. https://doi.org/10.1039/d4md00788c

Prodrugs: design and clinical applications. Nature reviews. Drug discovery, 7(3), 255–270. https://doi.org/10.1038/nrd2468

The expanding role of prodrugs in contemporary drug design and development. Nature reviews. Drug discovery, 17(8), 559–587. https://doi.org/10.1038/nrd.2018.46

Prodrug approach: An overview of recent cases. European journal of medicinal chemistry, 127, 810–827. https://doi.org/10.1016/j.ejmech.2016...

Prodrugs of NSAIDs: A Review. The open medicinal chemistry journal, 11, 146–195. https://doi.org/10.2174/1874104501711...