How do Senolytics Work to Target Senescent Cells | Dr. James Kirkland

Do you know what senescent (zombie) cells are and how cellular senescence and senolytics impact health?

This clip is from an episode of Longevity by Design; Hosts Ashley Reaver and Dr. Gil Blander are joined by Dr. James Kirkland from the Mayo Clinic, one of the world's leading figures in aging research. The episode is a deep dive into aging research, cellular senescence, and senolytics. Dr. Kirkland discusses the impact of cellular aging (senescence) on healthspan and his discovery of the first senolytic agents that remove senescent cells and extend healthspan, illuminating his pioneering work in aging research.

In the full discussion, we cover:

What is geroscience, and what are fundamental aging processes?
What are the differences between targeting aging vs. the traditional medical system of waiting to treat illnesses or diseases after they occur?
What are gerotherapeutics, and what is their relevance for healthspan and lifespan?:
What are senescent cells? What is the impact of senescent cells on the body and aging:
What are senolytics? How do senolytics work to target senescent cells to remove them?
How Dr. James Kirkland discovered senolytics such as fisetin, quercetin, and dasatinib? What clinical trials on the effects of senolytics in humans have been done?
Discovering biomarkers for senescent cells:
What are some important factors to consider on the effects of gerotherapeutics and senolytics on lifespan and healthspan in model organisms compared to humans?:
The potential for geroscience and gerotherapeutics, such as senolytics, to transform healthcare. What is the importance and what are some challenges of conducting clinical trials on gerotherapeutics, such as senolytics, to improve healthspan in humans?
What is the Translational Geroscience Network, and what are its goals?
How might senolytics be used clinically in the future if proven safe and effective? What conditions might they benefit?
What are the effects of lifestyle, such as diet and exercise, on senescent cells?
What excites Dr. James Kirkland the most about the potential for extending people's healthspan and lifespan with therapies, drugs, or interventions in the coming years?
Dr. Kirkland’s top tip for health?

Tune in to the full episode of Longevity By Design:    • The Effects of Cellular Senescence and Sen...  

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