Henning Fenselau – Neural Circuits Controlling Appetite and Energy Metabolism and GLP-1 Actions
Автор: BRAIN PONDERINGS podcast with Dr. Mark Mattson
Загружено: 2025-07-07
Просмотров: 203
Appetite (hunger and satiety) is controlled by neural circuits in the brain – particularly in the hypothalamus – and their reciprocal connections to peripheral organs involved in energy metabolism (gut and liver). Understanding the structural organization of these circuits (their synaptic connections) and their neurochemistry (particularly which neurotransmitters are used at which synapses) is of fundamental importance for human health and developing new treatments for metabolic disorders such as obesity and diabetes. Neuroscientist Henning Fenselau at the Max Planck Institute and University of Cologne Germany has made several major discoveries about how food intake and energy metabolism are regulated and the consequences of abnormalities in the underlying neural circuits. Among his recent findings concern how GLP-1 in the gut communicates with the brain via the vagus nerve, and the roles of specific synaptic signals (NPY, opioids, TRH, and GABA).
LINKS
Fenselau laboratory page: https://www.sf.mpg.de/research/fenselau
GLP-1, the vagus nerve, hunger, and sugar metabolism:
https://www.cell.com/action/showPdf?p...
Synaptic amplifier of hunger:
https://pmc.ncbi.nlm.nih.gov/articles...
Opioids and sugar appetite
https://www-science-org.proxy1.librar...
Brainstem – amygdala circuit during fasting
https://pmc.ncbi.nlm.nih.gov/articles...
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