Jonathan Long: Lactate-Phe and Ketone-Phe: Exerkines and Fastokines for Brain Health and Plasticity?
Автор: BRAIN PONDERINGS podcast with Dr. Mark Mattson
Загружено: 2025-06-24
Просмотров: 409
During vigorous exercise lactic acid (lactate) levels increase in the blood and during fasting and extended exercise the levels of the ketone BHB (-hydroxybutyrate) increase. In this episode I talk with Stanford University professor Jonathan Long about his recent discovery that lactate and BHB in the blood are bound to the amino acid phenylalanine and that they (Lac-Phe and BHB-Phe) have beneficial effects on metabolic and brain health. Lac-Phe levels increase markedly in response to exercise in mice, humans, and race horses. Peripheral administration of Lac-Phe in suppresses food intake and reverses diet-induced obesity and insulin resistance in mice. Genetic ablation of Lac-Phe biosynthesis causes hyperphagy and obesity even in exercising mice showing a critical role for Lac-Phe in the beneficial effects of exercise. BHB-Phe has similar effects on food intake and metabolic health. We talk about the potential benefits of Lac-Phe and BHB-Phe for brain health and resilience.
LINKS
The Long laboratory webpage: https://longlabstanford.org/
Lac-Phe articles:
https://pmc.ncbi.nlm.nih.gov/articles...
https://pmc.ncbi.nlm.nih.gov/articles...
BHB-Phe article: https://www.cell.com/action/showPdf?p...
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