Systemic Lupus Erythematosus Explained | Diagnosis, Antibodies & Management | CanadaQBank

In this high-yield rheumatology review, we explain Systemic Lupus Erythematosus (SLE) — a chronic autoimmune disease characterized by multisystem inflammation and autoantibody production.

This video covers pathophysiology, clinical manifestations, autoantibodies, diagnosis, and treatment strategies, making it ideal for USMLE Step 1, Step 2 CK, NCLEX, PLAB, PANCE, and medical & nursing exams.

What You Will Learn

Pathophysiology of systemic lupus erythematosus
Common clinical manifestations
Key autoantibodies and lab findings
Renal, neurologic, and hematologic involvement
Diagnostic approach
Evidence-based management


Key High-Yield Points

Autoimmune immune-complex–mediated disease
Anti–double-stranded DNA and anti-Smith antibodies
Low complement levels during flares
Malar rash and photosensitivity
Renal involvement: lupus nephritis
Treatment: hydroxychloroquine for all patients unless contraindicated

Common Complications Covered

Lupus nephritis
Central nervous system involvement
Hematologic abnormalities
Antiphospholipid antibody syndrome
Increased cardiovascular risk


Perfect For

Medical students and nursing students
USMLE Step 1 and Step 2 CK preparation
NCLEX, PLAB, and PANCE candidates
Rheumatology and internal medicine review


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#SystemicLupusErythematosus
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#LupusNephritis
#Immunology
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#PANCE
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