Everything I've Tried in 5 Years of Long Covid | Part 2

In this series of four videos I’m going to go through in detail every single treatment, supplement, medication or intervention I’ve tried in 5 years of suffering with Long Covid. I’m going to talk about the current theory, rationale or science for why each might be effective, and then discuss my experience with it, before sharing what the anecdotal reports are from others who’ve tried it, and whether it’s still a relevant part of the toolbox today.

It goes without saying, but I have to say it anyway, that several of these treatments are of course prescription only, and for the ones that aren’t, I have to insist that you speak to you doctor before trying them. I am not a doctor and I am explicitly not recommending anything that I talk about in this list.

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CHAPTERS
0:00 Intro
1:14 LDN
3:06 Acyclovir
4:10 Metformin
5:40 Corticosteroids
7:50 Anticoagulants
10:03 Natto/lumbrokinase
11:04 Nicotine Patches
13:06 Supplements

RESOURCES:

LDN:
Low-dose naltrexone use for the management of post-acute sequelae of COVID-19
https://www.sciencedirect.com/science...

Safety and efficacy of low dose naltrexone in a long covid cohort; an interventional pre-post study
https://pmc.ncbi.nlm.nih.gov/articles...

ACYCLOVIR:
Treatment of Long-Haul COVID Patients With Off-Label Acyclovir
https://pmc.ncbi.nlm.nih.gov/articles...

Acyclovir clinically resolved or significantly improved symptoms in patients diagnosed with long COVID syndrome:
https://discovermednews.com/long-covi...

METFORMIN
Can Metformin Treat Long COVID?
https://www.psychologytoday.com/us/bl...

Outpatient treatment of COVID-19 and incidence of post-COVID-19 condition over 10 months (COVID-OUT)
https://www.thelancet.com/journals/la...

ANTICOAGULANTS:
Anticoagulant therapy for COVID-19: What we have learned and what are the unanswered questions?
https://pmc.ncbi.nlm.nih.gov/articles...

Triple Coagulation Therapy Scores in Long COVID:
https://www.healthrising.org/blog/202...

Treatment of Long COVID symptoms with triple anticoagulant therapy:
https://www.researchsquare.com/articl...

NATTOKINASE / LUMBROKINASE:
Automated microscopic measurement of fibrinaloid microclots and their degradation by nattokinase, the main natto protease
https://www.biorxiv.org/content/10.11...

Degradative Effect of Nattokinase on Spike Protein of SARS-CoV-2
https://pmc.ncbi.nlm.nih.gov/articles...

NICOTINE PATCHES:
Is the post-COVID-19 syndrome a severe impairment of acetylcholine-orchestrated neuromodulation that responds to nicotine administration?
https://bioelecmed.biomedcentral.com/...

Could Nicotine Patches Help Treat Long COVID Symptoms?
https://www.verywellhealth.com/nicoti...

SUPPLEMENTS

B3 helps recovery from infection:
https://medicalxpress.com/news/2025-0...