A Clinical Yardstick for Managing Mast Cell Activation Syndrome (MCAS)

What is mast cell activation syndrome (MCAS) and how do doctors diagnose and treat it?

We review the article “Management of indolent mastocytosis and mast cell activation syndrome - A clinical yardstick,” published in June 2025 in The Annals of Allergy, Asthma & Immunology. The yardstick provides doctors with practical guidance on how to manage mast cell disorders while awaiting more comprehensive guidelines. Our hosts focus only on mast cell activation syndrome in this episode.

What you'll learn:
• What MCAS is and how it fits into mast cell disorders
• The three criteria doctors use to diagnose MCAS
• Treatment strategies: antihistamines, leukotriene blockers, cromolyn, aspirin, omalizumab, and epinephrine
• How triggers, brain fog, and anxiety affect patients with MCAS

INFOGRAPHIC to follow along
https://drive.google.com/file/d/1y2us...

Thanks to Blueprint Medicines for sponsoring today’s episode.

This podcast is for informational purposes only and does not substitute professional medical advice. Always consult with your healthcare provider for any medical concerns.

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