Histamine Intolerance and Hashimotos-The Thyroid Histamine Connection

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There is a bidirectional link between histamine intolerance and Hashimoto's, where one can exacerbate the other. Research shows that the chronic inflammation typical of Hashimoto's can activate immune cells called mast cells, which then release histamine. In turn, excessive histamine levels can worsen autoimmune inflammation and interfere with thyroid function.

The histamine-thyroid vicious cycle
Inflammation from autoimmunity: In Hashimoto's thyroiditis, the immune system attacks the thyroid gland, causing chronic inflammation. This inflammation signals mast cells throughout the body to activate and release stored histamine.

Hypothyroidism increases mast cells: Studies show that when thyroid function is low (hypothyroid), the number of mast cells in the body increases. This creates a greater capacity for histamine release, heightening the risk of histamine intolerance or mast cell activation syndrome (MCAS).

Histamine affects thyroid hormones: The surge of histamine can directly damage thyroid tissue and impede the absorption and conversion of thyroid hormones. High histamine levels can lower active triiodothyronine (T3) levels, worsening hypothyroid symptoms.

Antibodies activate mast cells: Autoantibodies associated with Hashimoto's, such as anti-TPO, can bind to mast cells and trigger them to release histamine. This suggests a self-perpetuating cycle where the immune response fuels further mast cell activation.

Gut health disruption: High histamine levels can increase gut permeability, allowing undigested food and other substances to enter the bloodstream. A "leaky gut" can trigger or worsen autoimmune reactions, further damaging the thyroid and promoting inflammation.

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