How Do Statins Affect Coenzyme Q10 Levels?

#functionalmedicine #statins #cholesterol #coq10 #supplements

Statins: How It Affects Coenzyme Q10 Levels?

Coenzyme Q10 (CoQ10) (2,3-dimethoxy-5-methyl-6-decaprenyl-1,4-benzoquinone) is a natural antioxidant synthesized by your body. It’s also known as “ubiquinone” because it is ‘ubiquitous’ in the human body. CoQ10 is used by every single cell.

CoQ10 is required for the energy production that takes place in your mitochondria . It takes fat and other substances and converts them into usable energy.

Coenzyme Q10 is an important factor in mitochondrial respiration. Primary and secondary deficiencies of coenzyme Q10 result in a number of neurologic and myopathic syndromes. Hydroxyl-methylglutaryl coenzyme A reductase inhibitors or statins interfere with the production of mevalonic acid, which is a precursor in the synthesis of coenzyme Q10. The statin medications routinely result in lower coenzyme Q10 levels in the serum. Some studies have also shown reduction of coenzyme Q10 in muscle tissue. Such coenzyme Q10 deficiency may be one mechanism for statin-induced myopathies.

Multiple studies have shown that statins can decrease coenzyme Q10 levels. A portion of this decrease is related to the decrease in the levels of its lipoprotein transport carriers, which is induced by the therapeutic effect of the statins.

Coenzyme Q10 is an important component of mitochondrial biochemistry, allowing for the production of ATP. HMA Co-A reductase inhibitors or statins inhibit one of the key steps in coenzyme Q10 synthesis. These drugs have been associated with a reduction in serum and muscle tissue coenzyme Q10 levels and may play a role in statin-induced myopathy.

Dosage:
200 mg - 400 mg

Statin Dose:
Statin dose + '0' = CoQ10 Dose
40 mg + 0 = 400 mg Dose

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Dr. Jawad is a Board Certified Chiropractic Neurologist and Acupuncturist. In addition, a Diplomat for the American Chiropractic Neurology Board, Fellow of the American College of Functional Neurology as well as Fellow of the International Academy of Medical Acupuncture. He is a Certified Functional Medicine Practitioner.

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