S01E01 | Vogt-Koyanagi-Harada Disease: Understanding and Management

Vogt-Koyanagi-Harada Disease: A Comprehensive Review of Immunopathogenesis, Diagnosis, and Management

DOI: 10.5281/zenodo.16291601

ABSTRACT
This podcast offers a comprehensive review of Vogt-Koyanagi-Harada (VKH) disease, a rare autoimmune disorder primarily affecting the eyes but also impacting the brain, inner ear, and skin. It delves into the immunopathogenesis, explaining how the immune system mistakenly attacks melanocytes, the cells responsible for pigment. The text also outlines the diagnostic criteria and the four distinct clinical stages of VKH, from early flu-like symptoms to vision loss and skin depigmentation. Crucially, it details the evolving therapeutic strategies, emphasizing the importance of early, aggressive, and sustained immunosuppression to prevent irreversible complications, and discusses the management of common vision-threatening issues like glaucoma and cataracts.

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OBJECTIVES
1. What is Vogt-Koyanagi-Harada (VKH) disease and what are its core characteristics?
2. What causes VKH disease, and who is most susceptible?
3. What are the main clinical stages of VKH disease, and what symptoms characterize each?
4. How is VKH disease diagnosed, and what other conditions must be ruled out?
5. What is the primary treatment strategy for VKH disease, and why has it evolved?
6. What are the potential long-term complications of VKH disease, and how are they managed?
7. What is the prognosis for VKH disease, and what factors influence it?
8. What are the key future directions in VKH research and treatment?

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