Reacting to Vitamin B12? 5 Reasons & How to Fix It!

Have you ever taken Vitamin B12 and felt worse—anxious, jittery, or unable to sleep? You’re not alone! In this video, I'll walk you through the 5 main reasons you're reacting to Vitamin B12 supplements, including key genetic factors like MTHFR, COMT, and MAOA. You’ll also learn practical tips on how to calm a reaction and how genetic testing can pinpoint your optimal form and dosage.

Stop guessing and start feeling better!

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🎥 This video was edited by:
Rahul Kanchi   / rahul-kanchi  

🚑 If you are in a mental health crisis, please dial 9-8-8 from the U.S. Or text HOME to 741741 and connect to a crisis counselor.
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References:
Benton, D., & Donohoe, R. T. (1999). The effects of nutrients on mood. Public health nutrition, 2(3A), 403–409. https://doi.org/10.1017/s136898009900...

James, S. J., Cutler, P., Melnyk, S., Jernigan, S., Janak, L., Gaylor, D. W., & Neubrander, J. A. (2004). Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. The American journal of clinical nutrition, 80(6), 1611–1617. https://doi.org/10.1093/ajcn/80.6.1611

MTHFR Support Australia. (2020). Neutralising a methyl reaction: Niacin antidote instructions. Retrieved June 2025, from https://mthfrsupport.com.au/2020/03/n...

Pavlov, C. S., Damulin, I. V., Shulpekova, Y. O., & Andreev, E. A. (2019). Neurological disorders in vitamin B12 deficiency. Terapevticheskii arkhiv, 91(4), 122–129. https://doi.org/10.26442/00403660.201...

Vitamin B-12: How much is too much? (2019, August 30). Www.medicalnewstoday.com. https://www.medicalnewstoday.com/arti...

What are the side effects of Mecobalamin? (2024). Patsnap.com. https://synapse.patsnap.com/article/w...

Disclaimer: All of the information on this channel is for educational purposes only and not intended to be specific/personal medical advice or substitute for diagnosis and treatment of any conditions discussed herein. Furthermore, watching these videos or getting answers to comments/questions, does not establish a provider-patient relationship. Please consult with your own healthcare provider for proper diagnosis and treatment.

Note: This video is not sponsored. Some of the links provided are affiliate links, meaning I may earn a small commission from purchases made through those links.

Timestamps:
0:00 - Intro: Why B12 Can Make You Anxious
1:06 - Symptoms of B12 Sensitivity
1:46 - Reason 1: You're Taking the Wrong Form
3:13 - Reason 2: Genetic Variants and Methylation
5:39 - Reason 3: Your Nervous System Is Overstimulated
6:43 - Reason 4: Missing Key Cofactors
7:47 - Reason 5: Histamine or Sulfur Sensitivity
8:38 - What to Do If You're Reacting to B12
9:40 - How Genetic Testing Can Help
10:15 - Conclusion & Call to Action