Debunking Sugar Claims: What Dr. Lustig Got Wrong On The Huberman Podcast

This week, Paul talks to Mike Fave, critical care RN about all things sugar & fructose. They share their thoughts on a recent podcast with Andrew Huberman and Alex Lustig, and why they disagree with certain points made about insulin, fruit juice, and fructose.

*Produced by ⁠Mountain Valley Media

00:00:00 Podcast begins
00:04:00 Mike’s background
00:05:15 Diving into fructose
00:13:00 Thoughts on honey and other carb sources
00:27:30 Robert Lustig rebuttal: is fructose addictive?
00:37:40 Fructose & fiber
00:47:00 How fructose affects the mitochondria
00:51:00 Clarifying hyperglycemia vs. a postprandial hyperglycemia
00:56:17 Is insulin the bad guy?
01:12:20 How insulin relates to diabetes, obesity, and insulin resistance
01:23:30 Balancing protein, fat and carbohydrates
01:30:00 Is fructose making us fat?
01:46:00 Final thoughts


Connect with Mike:
Mikefave.com
   / @mikefavesimplified  


References:
Review article: fructose malabsorption and the bigger picture: https://onlinelibrary.wiley.com/doi/1...

A Relationship between Reduced Nucleus Accumbens Shell and Enhanced Lateral Hypothalamic Orexin Neuronal Activation in Long-Term Fructose Bingeing Behavior: https://www.ncbi.nlm.nih.gov/pmc/arti...

A High-Fat Meal, or Intraperitoneal Administration of a Fat Emulsion, Increases Extracellular Dopamine in the Nucleus Accumbens: https://www.ncbi.nlm.nih.gov/pmc/arti...

A Relationship between Reduced Nucleus Accumbens Shell and Enhanced Lateral Hypothalamic Orexin Neuronal Activation in Long-Term Fructose Bingeing Behavior: https://www.ncbi.nlm.nih.gov/pmc/arti...

The regulation of glucose metabolism: implications and considerations for the assessment of glucose homeostasis in rodents: https://journals.physiology.org/doi/f...

Consumption of Raw Orange, 100% Fresh Orange Juice, and Nectar- Sweetened Orange Juice—Effects on Blood Glucose and Insulin Levels on Healthy Subjects: https://www.ncbi.nlm.nih.gov/pmc/arti...

The Effects of Soluble Dietary Fibers on Glycemic Response: An Overview and Futures Perspectives: https://www.ncbi.nlm.nih.gov/pmc/arti...

The Effects of Soluble Dietary Fibers on Glycemic Response: An Overview and Futures Perspectives: https://www.ncbi.nlm.nih.gov/pmc/arti...

Formation of Fructose-Mediated Advanced Glycation End Products and Their Roles in Metabolic and Inflammatory Diseases: https://www.ncbi.nlm.nih.gov/pmc/arti...

Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM: https://pubmed.ncbi.nlm.nih.gov/9216960/

Glucagon and type 2 diabetes: the return of the alpha cell: https://pubmed.ncbi.nlm.nih.gov/25344...

Insulin, growth hormone and sport: https://pubmed.ncbi.nlm.nih.gov/11431...

Effect of Mild Physiologic Hyperglycemia on Insulin Secretion, Insulin Clearance, and Insulin Sensitivity in Healthy Glucose-Tolerant Subjects: https://www.ncbi.nlm.nih.gov/pmc/arti...

Fructose metabolism in humans – what isotopic tracer studies tell us: https://www.ncbi.nlm.nih.gov/pmc/arti...

Absorption capacity of fructose in healthy adults. Comparison with sucrose and its constituent monosaccharides: https://www.ncbi.nlm.nih.gov/pmc/arti...

Review article: fructose malabsorption and the bigger picture: https://onlinelibrary.wiley.com/doi/1...

Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice: https://pubmed.ncbi.nlm.nih.gov/19637...

Fructose Promotes Leaky Gut, Endotoxemia and Liver Fibrosis through CYP2E1-Mediated Oxidative and Nitrative Stress: https://www.ncbi.nlm.nih.gov/pmc/arti...